Yes, the progression of fatigue differs between eccentric and concentric phases. But there are also differences in the nature of the fatigue between the eccentric and concentric phases, which affects how hypertrophy can be stimulated.

I just published this new article that describes how that physiology works, which may be useful to you: https://sandcresearch.medium.com/why-does-eccentric-overload-training-not-cause-more-hypertrophy-than-normal-strength-training-a06befa863d5