What causes delayed onset muscle soreness (DOMS)?

What are the possible mechanisms of DOMS?

Introduction

  1. why DOMS is greater after exercise that is unaccustomed compared to exercise that is accustomed (this is called the repeated bout effect, and it lasts for at least 6 weeks and possibly even longer);
  2. why DOMS is greater after eccentric than concentric contractions (but does still occur after concentric-only exercise, contrary to some statements on this subject);
  3. why DOMS does not appear immediately after exercise, but appears gradually and reaches a peak between 24 and 72 hours after exercise (this is the biggest challenge for understanding DOMS, since it separates any damaging event during exercise from the subsequent pain);
  4. why DOMS tends to occur more in certain regions of the exercised muscles than in others (indeed, some research has found that the most distal parts of the muscle experience the most DOMS, while other research suggests that the most affected sites can vary, and some studies have even found that the exact location varies between individuals).

#1. Lactic acid (lactate and hydrogen ions)

#2. Reflex spasms

#3. Muscle damage

#4. Connective tissue damage

#5. Muscle fiber inflammation

#6. Connective tissue inflammation

#7. Muscle fiber swelling

#8. Connective tissue swelling

#9. Neurotrophic signaling

#10. Oxidative stress (including nitric oxide)

#11. Muscle spindle nerve damage

What are the likely mechanisms of DOMS?

What is the takeaway?

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Figuring out how strength training works. See more of what I do: https://www.patreon.com/join/SandCResearch

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Chris Beardsley

Chris Beardsley

Figuring out how strength training works. See more of what I do: https://www.patreon.com/join/SandCResearch

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